Funding Source: U.S. Department of Defense (W81XWH2010432)

Jeffrey Hasday, MD

Principal Investigator, University of Maryland Medical Center

Dr. Hasday is board-certified in internal medicine, pulmonary medicine, and critical care medicine and is head of the division of pulmonary and critical care medicine at the University of Maryland School of Medicine Department of Medicine. He has over 30 years of experience as a pulmonary and critical care physician with clinical expertise in with acute lung injury/ARDS, sepsis/septic shock, interstitial lung disease, and asthma. His basic and translational research focuses on thermobiology and the effects of clinically relevant hypothermia and hyperthermia (including fever) on biological processes that contribute to homeostasis and disease pathogenesis. His specific research interests include p38 MAP kinase signaling and development of substrate-selective p38 inhibitors, TRPV4, endothelial barrier function, regulation of cytokine expression, acute lung injury, regulation of heat shock protein gene expression, therapeutic hypothermia in ARDS, and thermoregulation. Dr. Hasday directs the University of Maryland Cytokine Core Laboratory.

Carl Shanholtz, MD

Director, Clinical Coordinating Center (CCC), University of Maryland Medical Center

Dr. Shanholtz is the University of Maryland Medical Center (UMMC) Medical Intensive Care Unit (MICU) medical director, the medical director of the UMMC Department of Respiratory Care, and was an ARDSnet Principal Investigator (PI). He has had a longstanding interest in improving the management of critically ill patients. Dr. Shanholtz has been involved in clinical research in critical illness in general, and acute respiratory distress syndrome specifically, for over 20 years. He began his research career with Roy Brower in 1991 while a fellow in critical care medicine at the Johns Hopkins University School of Medicine and has collaborated on clinical research projects thereafter. Shortly after receiving a faculty appointment at the University of Maryland School of Medicine, Dr.  Shanholtz helped organize a four-hospital consortium in Baltimore to conduct a phase II clinical trial (n= 52 patients) of low tidal volume ventilation to reduce the risk of ventilator-induced lung injury in patients with the acute respiratory distress syndrome (ARDS). The methodology and experience of this study provided a substantial basis for the large, phase III trial of mechanical ventilation with lower tidal volumes in ARDS subsequently conducted by the original ARDSnet and chaired by Dr. Brower. Dr. Shanholtz was later the University of Maryland School of Medicine site PI for three clinical projects as part of an NIH NHLBI-sponsored grant for a Specialized Center for Clinically Oriented Research in Acute Lung Injury (ALI SCCOR). Dr. Shanholtz has worked with the Chief of the University of Maryland Division of Pulmonary and Critical Care Medicine, Dr. Hasday, for the past 20 years. Dr. Shanholtz was a multiple PI recently on an NIH NINR-funded project for the management of acute pain in non-communicative critically ill patients.

Michael Terrin, MDCM, MPH

Director, Data Coordinating Center (DCC), University of Maryland, Baltimore

Dr. Michael Terrin is an internist with subspecialty certification in pulmonary medicine, and an MPH in epidemiology. Dr. Terrin has directed or been deputy director of Coordinating Centers for more than 25 studies with emphases on clinical trials and cohort studies. In 1979-1982, he held a cardiovascular epidemiology training grant at the Johns Hopkins University School of Hygiene and Public Health. He led the Data Coordinating Center for the NHLBI-sponsored Multicenter Study of Hydroxyurea (MSH) in Sickle Cell Anemia and for the NHLBI-sponsored FOCUS clinical trial comparing transfusion strategies. He was responsible for the data coordination of a landmark study in pulmonary embolism (PIOPED) and Deputy Director for the portion of the first NHLBI-initiated thrombolytic agent clinical trials, TIMI I and TIMI II, that discovered t-PA’s dose and patient characteristic-dependent risk of cerebral hemorrhage in acute myocardial infarction. Recently, he has been contact and Data Coordinating Center (DCC) Principal Investigator for the NIA-sponsored Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA³CT) and Principal Investigator for the NHLBI Progenitor Cell Biology Consortium (PCBC) Administrative Coordinating Center. He is DCC Principal Investigator for the NICHD-sponsored Azithromycin to Prevent BPD in Ureaplasma-Infected Preterms (AZIP3), and Principal Investigator for the NHLBI Progenitor Cell Translational Consortium (PCTC) Administrative Coordinating Center. Dr. Terrin is co-Principal Investigator of the Biostatistics and Bioinformatics Core (Core 1) of the University of Maryland, Baltimore, Older Americans Independence Center (Claude D. Pepper Center). He is the Principal Investigator for the NIAID-funded Centers for Medical Counter Measures against Radiation Consortium (CMCRC) Consortium-wide Coordinating Center. Dr. Terrin is a faculty member in the Department of Epidemiology and Public Health, Division of Gerontology, and on the Department’s training grant (T32) for the Epidemiology of Aging. He has dedicated his career to the design, conduct, and analysis of clinical investigations with an emphasis on coordinating center data functions.

Clayton Brown, PhD

Biostatistician, Data Coordinating Center (DCC), University of Maryland, Baltimore

Dr. Brown is a biostatistician and Professor in the Department of Epidemiology and Public Health.  He is also the Director of the Biostatistics Unit in the V.A. Capitol Healthcare Network MIRECC (Mental Illness, Research, Education and Clinical Center).  He collaborates with a wide range of scientists and clinician investigators in medicine, epidemiology, health services, and behavioral interventions research. He has mentored multiple career development awardees (K’s, VA CDA’s) in statistics and served as a statistical consultant/mentor for the NIMH-funded Summer Research Institute in Geriatric Psychiatry for four years.

Current Clinical Sites

See the contacts page for a directory of PIs and site staff.

#1 University of Maryland Medical Center

#2 Brooke Army Medical Center

#4 Cleveland Clinic

#5 Emory University

#7 Johns Hopkins University

#8 Thomas Jefferson Medical Center

#10 University of Pennsylvania

#11 Rush University Medical Center

#12 Temple University Medical Center

#15 Wisconsin University

#16 Intermountain Healthcare      

#17 Cooper Healthcare      

#18 Yale University

#19 Oregon Health & Science University